Best Home Run Predictions Today: MLB Odds, Picks & Prop Bets for June 22

Pete Alonso will look to keep his hot bat going tonight during a division-rivalry clash on Sunday Night Baseball.

Sean Tomlinson

Last Updated: June 22, 2025 1:45 PM EDT • 4 minute read

Home Run Predictions Today — Pictured New York Mets first baseman Pete Alonso reacts after a double during the fourth inning against the Tampa Bay Rays. Photo by Vincent Carchietta / Imagn.

Everyone's favorite baseball-mashing polar bear Pete Alonso will look to continue his sweet-swinging ways tonight in prime time on Sunday Night Baseball, and we're leaning on him as part of our best home run predictions today.

We've teed up an alluring home run parlay that will pay out $1,300 if it hits!

💰 MLB best home run predictions & odds today: June 22

Here are my best MLB home run predictions and odds today, with my pick confidence based on a 1-to-5-star scale. You can also check out our MLB player prop odds tool for the latest MLB odds at the best legal sportsbooks in your region while making your best home run bets today.

🧨 Pete Alonso player prop pick: To hit a home run (+320 via FanDuel) ⭐⭐⭐⭐⭐
🧨 Josh Naylor player prop pick: To hit a home run (+500 via bet365) ⭐⭐⭐⭐
🧨 Elly De La Cruz player prop pick: To hit a home run (+420 via FanDuel) ⭐⭐⭐⭐
🧨 Oneil Cruz player prop pick: To hit a home run (+310 via FanDuel) ⭐⭐⭐⭐

🚀 Best home run parlay picks

Here is our best MLB home run parlay for Sunday's baseball action; use our parlay calculator to get the best odds for any parlay.

💣 Pete Alonso to hit a home run (+320 via FanDuel)
💣 Josh Naylor to hit a home run (+500 via FanDuel)
💣 Elly De La Cruz to hit a home run (+420 via FanDuel)
💣 Oneil Cruz to hit a home run (+310 via FanDuel)

Parlay odds: +13004 via FanDuel ($10 to win $1,300.04)

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💣 Best home run prediction today: MLB expert picks & prop bets

Here are my best home run bets today. Check out the rest of our MLB picks along with our guide on how to bet on MLB.

⚾ Pete Alonso (Mets) to hit a home run ⭐⭐⭐⭐

Best odds: +320 via FanDuel (bet $10 to win $32)

FanDuel is offering +320 for Alonso to launch one tonight, which implies a 23.81% probability. Meanwhile, DraftKings is down at +285, with Caesars even further at +270. The latter implies a notably higher probability of 27.03%.

Pinnacle, with its industry-leading trading team, is splitting the difference and listing Alonso at +299, which still leads to a wide gap to FanDuel's number, making it the only book well above +300.

It's all highly appealing for a regular baseball punisher. Ride Alonso while he's sizzling, as the first baseman has put a poor second month of the season far behind him with his 1.049 OPS in June, which towers above a .649 during May.

That turnaround is unsurprising too since his underlying metrics are dripping with red at Baseball Savant, most impressively an average exit velocity and hard-hit percentage that rank among the top 3% leaguewide. He'll face Jesus Luzardo to start tonight, and his four-seamer has been getting pounded to the tune of a .518 slugging percentage allowed.

Meanwhile, our Mike Spector is eyeing another New York slugger to go deep in his Mets vs. Phillies player props ahead of a game he also broke down in our Mets vs. Phillies prediction and odds for Sunday Night Baseball.

📊 Mets vs. Phillies odds

🔮 Sunday Night Baseball expert picks

❓Best home Run predictions FAQs

What is a home run bet?

A home run bet is a wager on a specific player to hit a home run in a game. Our best MLB betting sites offer odds for most players involved in every game, especially those in the starting lineup.

Can you parlay home run bets?

Most of our best sports betting sites do allow you to parlay home run bets, which typically leads to lengthy plus-money odds.

How do I place a home run bet?

Go to one of our best sports betting apps and select a game for that day's slate. Within that game you'll usually see odds for a player "to hit a home run." Some books like Caesars also make the process even easier while offering a category for home runs and listing all the odds for that day on one page.

What are the best home run props for tonight?

We're eyeing Pete Alonso (+320) to hit a round-tripper on Sunday Night Baseball, along with Josh Naylor (+500), Elly De La Cruz (+420), and Oneil Cruz (+310).

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Written by:
Sean Tomlinson

Sean Tomlinson has been in the sports media wilderness since 2009, and he joined Sportsbook Review in 2021. His work has been referenced in The New York Times and Forbes. He's also made appearances on The Fan 590 and TSN 1050. Sean is a regular bettor who places bets daily while using a handful of books. Most frequently, he uses FanDuel and bet365 due to the quality experience on those apps. While he'll often take an analytical approach, Sean enjoys the fun, recreational side of betting too, and embraces alternative markets on events like the Westminster Dog Show or Eurovision, or the many novelty props tied annually to the Super Bowl, for example. Beyond sports, Sean is also interested in the betting markets tied to politics, and especially those connected to American elections. He sees betting as a way to explore and engage in a deeper way, and takes that same view to his work. He plays poker periodically too, and is an avid fantasy sports player. Sean also previously spent time with Bleacher Report and theScore, all after earning his media studies degree from the University of Guelph-Humber.