Best Home Run Predictions Today: MLB Odds, Picks & Prop Bets for June 5

We look to Freddie Freeman and Kyle Schwarber to save us from a home run predictions slump today.

Gabe Henderson

Last updated: June 5, 2025 11:24 AM EDT • 3 min read

Home Run Predictions Today: Best MLB Odds, Picks & Prop Bets for June 5 — Pictured: Chicago Cubs first baseman Michael Busch (29) hits a solo home run against the Washington Nationals. Photo by Brad Mills via Imagn Images.

The Chicago Cubs have one of baseball's best offenses, but after being blanked last night, can they bounce back? We're looking to capitalize on the Cubs' resurgence by betting on Michael Busch to hit a long ball in our home run predictions and parlay today.

Read on to reveal our best predictions and home run parlay, which pays out nearly $4,400 in profits on a $10 winning wager!

💰 MLB best home run predictions & odds today: June 5

Here are my best MLB home run predictions and odds today with my pick confidence based on a 1-to-5-star scale. You can also check out our MLB player prop odds tool for the latest MLB odds at the best legal sportsbooks in your region.

🧨 Michael Busch to hit a home run (+400 via FanDuel) ⭐⭐⭐
🧨 Kyle Schwarber to hit a home run (+310 via bet365) ⭐⭐⭐
🧨 Freddie Freeman to hit a home run (+500 via bet365) ⭐⭐
🧨 Wyatt Langford to hit a home run (+400 via BetMGM) ⭐⭐⭐

🚀 Best home run parlay picks

Here is our best MLB home run parlay for Thursday's baseball action; use our parlay calculator to get the best odds for any parlay.

💣 Michael Busch to hit a home run (+400 via FanDuel)
💣 Kyle Schwarber to hit a home run (+280 via FanDuel)
💣 Freddie Freeman to hit a home run (+480 via FanDuel)
💣 Wyatt Langford to hit a home run (+300 via FanDuel)

Parlay odds: +43980 via FanDuel ($10 to win $4,398)

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💣 Best home run prediction today: MLB expert picks & prop bets

Here's my best home run prop prediction today. Check out the rest of our MLB picks along with our guide on how to bet on MLB.

⚾ Michael Busch (Cubs) to hit a home run ⭐⭐⭐

Best odds: +400 via FanDuel (bet $10 to win $40)

While plenty of MLB players fly under the radar, Busch is among the most prominent relative to his production. He's got the eighth-best wRC+ in the National League (152), and he's a big reason Chicago ranks second in the league in runs scored.

Busch has been a right-handed pitcher's worst nightmare this season, slashing .297/.390/.570 in 158 at-bats. Those numbers improve to .306/.382/.612 on the road, where he thrives. The 27-year-old also clubbed all nine of his home runs on the year against righties - seven on the road - including Washington's Zach Brzykcy on Tuesday.

This is all bad news for Nationals starter Jake Irvin, who has allowed opposing hitters to take him yard at one of the league's highest clips. While he's gone three consecutive starts without giving up a round-tripper, he's still among the MLB leaders in home runs allowed with 10 across 73 1/3 innings pitched this year.

The Cubs' bats fell flat in a 2-0 loss to the Nats last night, so we're expecting Busch and Co. to come out swinging tonight. Our best sports betting sites list him at +400, meaning a $10 wager returns $40 in profits if the first baseman hits a homer in the series finale.

📊 Cubs vs. Nationals odds

💵 Best MLB betting sites

Want to bet on baseball? Check out the best MLB betting sites and best sportsbook promos for today's games:

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Written By:
Gabe Henderson

Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC.