Cardinals vs. Pirates Prediction, Odds & Best Bets: Who Stays Hot?

The Cardinals and Pirates enter today's series off weekend sweeps, and we dive into which NL Central team can keep it rolling.

Shane Jackson

Last Updated: June 30, 2025 10:25 AM EDT • 2 minute read

Cardinals vs. Pirates Prediction, Odds & Best Bets: Monday, June 30 — Pictured: Pittsburgh Pirates left fielder Tommy Pham gestures to the bullpen as he circles the bases on a solo home run. Photo by Charles LeClaire via Imagn Images.

With both teams coming off weekend sweeps, the St. Louis Cardinals (47-38) and Pittsburgh Pirates (38-50) will clash today at PNC Park. Our Cardinals vs. Pirates prediction will have you ready for the 6:40 p.m. ET first pitch.

This matchup is considered a toss-up based on the betting odds, following St. Louis' sweep of the Cleveland Guardians and Pittsburgh's win over all three games against the New York Mets. Read on to see who we prefer in this NL Central matchup.

Cardinals vs. Pirates prediction: Pirates to win (-108 via FanDuel) ⭐⭐⭐⭐
Over/Under prediction: Over 8.5 (-118 via BetMGM) ⭐⭐
Best player prop pick: Adam Frazier Over 1.5 hits, runs, and RBIs (-130 via DraftKings) ⭐⭐⭐

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The Pirates scored 30 runs over the weekend against the Mets, a promising sign for a lineup that hasn’t played well enough to stay relevant.

Pittsburgh ranks 28th in the league in wRC+ (81) over the full season, but that mark jumps up to 114 (11th in MLB) during a 6-4 stretch over the last 10 games. The Pirates are 8-2 to the Over during that span.

The Cardinals also scored 21 runs over the weekend, but a matchup against left-hander Andrew Heaney might stop the momentum. St. Louis has a wRC+ of 93 against left-handed pitchers this season.

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Written by:
Shane Jackson

Shane Jackson has been writing for Sportsbook Review since 2022, though his passion for sports, writing, and betting runs much longer than that. He graduated from the University of Kansas with a journalism degree in 2017 and has been covering sports ever since, working for MLB.com, Manhattan Mercury, Lawrence Journal-World, WynnBET, Bet Chicago Sports, BetNOLA, and BetMGM. Jackson cares about creating quality sports betting content above all else. He uses a mixture of models, information, film, analysis, and a top-down approach to locate every best bet shared for SBR. He never gives out a pick that he wouldn’t be willing to spend his own money on. Jackson is focused on finding +EV bets on a daily basis for a variety of sports such as NCAAF, NCAAB, NFL, NBA, WNBA, and MLB. He usually bets on props but is willing to wager on a spread or total when there is an edge. Don’t ask him how many bets he has placed on a typical college football Saturday. Jackson doesn’t care if you follow him on social media, but his Twitter account has info on how you can follow his bets through multiple third-party platforms. He just wants you to read all the great work from the SBR team.