Guardians vs. Cubs Prediction, Odds & Best Bets: Believe in Boyd

We're looking at the Guardians vs. Cubs game and asking whether Matthew Boyd can limit Cleveland enough to earn his team the win.

Andrew Brennan

Last Updated: July 1, 2025 3:02 PM EDT • 2 minute read

Guardians vs. Cubs Prediction, Odds & Best Bets: Tuesday, July 1 — Pictured: Chicago Cubs starting pitcher Matthew Boyd headlines our Guardians vs. Cubs prediction today. Photo by Geoff Burke via Imagn Images.

The Cleveland Guardians (40-42) carry a four-game losing skid into their series opener against the Chicago Cubs (49-35) at 8:05 p.m. ET on Tuesday at Wrigley Field.

The latest betting odds expect that streak to continue, as Chicago is a sizable favorite in a pitching matchup between left-hander Matthew Boyd and right-hander Gavin Williams. Our Guardians vs. Cubs prediction believes there is still value in backing the home team.

Guardians vs. Cubs prediction: Cubs to win (-170 via Caesars) ⭐⭐⭐
Over/Under prediction: Under 8 (-112 via DraftKings) ⭐⭐
Best player prop pick: Steven Kwan Under 1.5 H+R+RBI (-115 via DraftKings) ⭐⭐⭐

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Despite moving 10 cents overnight, there is still value in taking the Cubs’ moneyline at -175 or better before first pitch. Chicago is as high as -181 at our best sports betting sites, indicating belief in the home team.

That’s because the Cubs have an elite offense, ranking third in MLB with a wRC+ of 115. They are one or two pitching reinforcements away from being legitimate World Series odds contenders in a top-heavy National League.

That said, Boyd has been plenty good enough on the mound this season. He has a 2.65 ERA, which ranks 12th in all of baseball. He tossed six shutout innings against the St. Louis Cardinals last time out, finishing June with a 1.78 ERA in five starts.

Chicago is the deserving favorite on Tuesday.

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Written by:
Andrew Brennan

Andrew Brennan is a publishing editor for Sportsbook Review. He also heads the website’s MLB coverage, from the various futures markets to daily picks. Andrew believes a math-based approach is the best way to enjoy long-term success in sports betting, and he’s spent the better part of the last year fine-tuning his own process for MLB, NBA, and NFL picks. Andrew uses eight different sportsbooks to find the best odds available and various projection models to gather as much information as he can. His most used sportsbooks are bet365, FanDuel, and theScore Bet. When it comes to daily projection models, he regularly references NumberFire across all sports, as it’s one of the best free tools available. In terms of which daily markets Andrew attacks, he almost exclusively bets on pitcher strikeouts for baseball. When the winter rolls around, you’ll see him providing more variety when it comes to the NBA (points, assists, rebounds) and NFL (almost any offensive-based player prop). He used these tools to go +150 units in 2023. Andrew is also a passionate fantasy sports player. He’s played fantasy football, fantasy Premier League, and fantasy baseball for the last decade. He graduated from Durham College with his diploma in journalism after earning his degree in law from Carleton University. He’s worked in sports media since early 2017, first contributing at FanSided before moving to theScore. He joined SBR in 2022.