Guardians vs. Cubs Prediction, Odds & Best Bets: Plenty of Offense Coming at Wrigley

In an exciting pitching showdown between Tanner Bibee and Shota Imanaga, is it possible we get an explosion of runs at Wrigley Field?

Andrew Brennan

Last Updated: July 2, 2025 4:30 PM EDT • 3 minute read

There's an exciting pitching matchup ahead tonight at Wrigley Field, but my Guardians vs. Cubs prediction expects the offenses to shine when this one gets underway at 8 p.m. ET on ESPN.

Kyle Tucker has been sizzling for the Cubs, who are coming off a 5-2 win last night in Game 1 of this series. Chicago serves as the betting favorite for this one, and I think it'll rise up again in somewhat of a slugfest.

Guardians vs. Cubs prediction: Cubs to win (-160 via Caesars) ⭐⭐⭐
Over/Under prediction: Over 8.5 (+105 via ESPN BET) ⭐⭐⭐
Best player prop pick: Kyle Tucker Over 1.5 total bases (+105 via DraftKings) ⭐⭐⭐⭐

⚾ Guardians vs. Cubs predictions & odds

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💰 Guardians vs. Cubs prediction & best bet

✅ Best bet: Kyle Tucker Over 1.5 total bases (+105 via DraftKings)

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Tucker has been incredible in his first season with the Cubs. He ranks sixth in the league in fWAR and looks to be on track to become the second player to join the 20-20 club this season - the first being his teammate, Pete Crow-Armstrong.

He went a bit cold at the beginning of June, but is once again red-hot at the plate. He owns a 1.022 OPS during the last two weeks, and he's hit four home runs in 49 at-bats in that time.

Tucker's .290 average represents a career high, and he's also on pace to set a new career-best mark in home runs. Let's back one of the MLB MVP odds contenders to have a big day with our Guardians vs. Cubs prediction.

Guardians vs. Cubs betting insights

Here are some betting insights from BetMGM before the Guardians vs. Cubs game begins.

There's a clear lean toward the Cubs on the moneyline, with Chicago drawing 68% of the bets and 82% of the handle
There's more of a divide on the total of 8 runs, with the Over getting a very narrow edge at 52% of the bets, while the Under is receiving 87% of the action
The Cubs are drawing nearly all the run-line action while getting 95% of the bets and 97% of the handle to cover -1.5

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Written by:
Andrew Brennan

Andrew Brennan is a publishing editor for Sportsbook Review. He also heads the website’s MLB coverage, from the various futures markets to daily picks. Andrew believes a math-based approach is the best way to enjoy long-term success in sports betting, and he’s spent the better part of the last year fine-tuning his own process for MLB, NBA, and NFL picks. Andrew uses eight different sportsbooks to find the best odds available and various projection models to gather as much information as he can. His most used sportsbooks are bet365, FanDuel, and theScore Bet. When it comes to daily projection models, he regularly references NumberFire across all sports, as it’s one of the best free tools available. In terms of which daily markets Andrew attacks, he almost exclusively bets on pitcher strikeouts for baseball. When the winter rolls around, you’ll see him providing more variety when it comes to the NBA (points, assists, rebounds) and NFL (almost any offensive-based player prop). He used these tools to go +150 units in 2023. Andrew is also a passionate fantasy sports player. He’s played fantasy football, fantasy Premier League, and fantasy baseball for the last decade. He graduated from Durham College with his diploma in journalism after earning his degree in law from Carleton University. He’s worked in sports media since early 2017, first contributing at FanSided before moving to theScore. He joined SBR in 2022.