Guardians vs. Cubs Prediction, Odds & Best Bets: Can Chicago Pull Off Sweep at Home?

The Cubs won each of the first two games of this series, and we're backing one of their star players to carry the load in what should be a third straight victory against the Guardians.

Andrew Brennan

Last Updated: July 3, 2025 4:49 PM EDT • 3 minute read

Guardians vs. Cubs Prediction — Pictured Chicago Cubs outfielder Kyle Tucker is greeted in the dugout after scoring. Photo by David Banks / Imagn.

Chicago snatched the first two games of this series at home and has earned the opportunity to sweep Cleveland tonight at Wrigley Field, and our Guardians vs. Cubs prediction believes Kyle Tucker will play a key role in another victory for his club.

This one gets underway at 8:05 p.m. ET (MLB Network), and the pitching matchup is a real who's who (but seriously, who are these guys?). "Joey Cantillo" will take on "Cade Horton." Oh yeah, this baby is going Over.

Guardians vs. Cubs prediction: Cubs to win (-140 via bet365) ⭐⭐⭐
Over/Under prediction: Over 8.5 (-110 via Caesars) ⭐⭐⭐⭐
Best player prop pick: Kyle Tucker to hit a home run (+475 via bet365) ⭐⭐⭐⭐

⚾ Guardians vs. Cubs predictions & odds

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💰 Guardians vs. Cubs prediction & best bet

✅ Best bet: Kyle Tucker to hit a home run (+475 via bet365)

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Tucker's relatively long home run odds are a product of the Guardians sending a left-hander to the mound to start the game. That doesn't scare me in the slightest, as Tucker has been crushing southpaws this season.

In fact, Tucker is averaging fewer at-bats per home run against lefties (six in 103) than against righties (11 in 218). The only thing Tucker doesn't do quite as well against left-handed pitchers is take walks. To which we say, swing away big fella.

Tucker produced a monster game against the Houston Astros to start the week, but he's since gone the last three without a homer. I'm betting that changes tonight. Look for King Tuck to contribute to a high-scoring win for the Cubbies.

📈 Guardians vs. Cubs betting insights

Here are some betting insights from BetMGM during the hours before first pitch:

The moneyline hasn't moved much, with the Cubs getting a slight edge while drawing 59% of the tickets and 57% of the handle
Meanwhile, bettors seem torn regarding the total, with the Over getting 54% of the bets, but the Under drawing 53% of the handle
However, there's a clear lean on the run line, with the Cubs getting 80% of the bets and 94% of the handle to cover -1.5

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Written by:
Andrew Brennan

Andrew Brennan is a publishing editor for Sportsbook Review. He also heads the website’s MLB coverage, from the various futures markets to daily picks. Andrew believes a math-based approach is the best way to enjoy long-term success in sports betting, and he’s spent the better part of the last year fine-tuning his own process for MLB, NBA, and NFL picks. Andrew uses eight different sportsbooks to find the best odds available and various projection models to gather as much information as he can. His most used sportsbooks are bet365, FanDuel, and theScore Bet. When it comes to daily projection models, he regularly references NumberFire across all sports, as it’s one of the best free tools available. In terms of which daily markets Andrew attacks, he almost exclusively bets on pitcher strikeouts for baseball. When the winter rolls around, you’ll see him providing more variety when it comes to the NBA (points, assists, rebounds) and NFL (almost any offensive-based player prop). He used these tools to go +150 units in 2023. Andrew is also a passionate fantasy sports player. He’s played fantasy football, fantasy Premier League, and fantasy baseball for the last decade. He graduated from Durham College with his diploma in journalism after earning his degree in law from Carleton University. He’s worked in sports media since early 2017, first contributing at FanSided before moving to theScore. He joined SBR in 2022.