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Final Four Odds & Betting Lines: Duke, Auburn, Florida, Houston Earn No. 1 Seeds

Rob Paul

Last Updated: March 16, 2025 11:25 PM EDT • 2 min 35 sec read.

Final Four Odds & Updated Betting Lines: March Madness Picks 2025
Pictured: Duke Blue Devils guard Kon Knueppel (7) celebrates with teammates. Photo by Jim Dedmon-Imagn Images.

Duke, Auburn, and Florida are the most significant favorites by the Final Four odds following Selection Sunday and the 2025 bracket reveal. Those three teams and Houston earned the four No. 1 seeds in the bracket, and are the favorites to win their respective regions and advance to the Final Four in San Antonio on Saturday, April 5.

Duke sits atop the March Madness odds, and its Final Four odds after the bracket reveal mirror those numbers. Duke will begin its 2025 NCAA Tournament on Friday, and star Cooper Flagg is expected to be back in the lineup.

Use these odds to help you with your March Madness bracket.

4️⃣ Final Four odds 2025

With the 2025 March Madness bracket now set our March Madness betting sites replaced the Final Four odds market with odds to win each respective region. Throughout the NCAA Tournament, visit Sportsbook Review to get the best college basketball prop bets today.

A custom graphic of our March Tourney Survivor contest with $1,000 cash to the winner!
A custom graphic of our March Tourney Survivor contest with $1,000 cash to the winner!

Odds to win the East region

The East region will go through Duke, which remains the consensus betting favorite to win March Madness:

Odds to win the Midwest region

Houston is the favorite in the Midwest region, although the competition is closer than in the East with Tennessee (+370) having the shortest odds of the four No. 2 seeds in the tournament,

Odds to win the South region

Auburn's given even money and a 50% implied probability of winning the South region. Michigan State (+490) is well back as the closest competition.

Odds to win the West region

Florida moved to second on the March Madness oddsboard beyond Duke after earning a No. 1 seed. It's a heavy favorite to win the West. Third-seeded Texas Tech has shorter odds to win this region than No. 2 St. John's.

🔢 Final Four betting history

Here is a look at Final Four odds history. UConn had +2000 pre-season odds last season. The year prior the Huskies had +8000 odds.

YearMarch Madness championPreseason Final Four odds
2023-24UConn+2000
2022-23UConn+8000
2021-22Kansas+1400
2020-21Baylor+800
2018-19Virginia+1350
2017-18Villanova+2700
2016-17North Carolina+1900
2015-16Villanova +2500
2014-15Duke+900
2013-14Connecticut +6500
2012-13Louisville+700

❓March Madness FAQs

Who is the 2025 Final Four odds favorite? 

Duke is the biggest favorite to reach the Final Four in San Antonio in April. The Blue Devils' odds (-125) imply a 55.56% probability they'll reach the Final Four.

Where is the 2025 Final Four going to be played?

The 2025 Final Four will be played April 5 and 7 at Alamodome in San Antonio.

Who was the Final Four favorite last year?

The Huskies were the consensus betting favorites with odds as short as -455 to reach the Final Four during March Madness last year. Those odds gave the Huskies an implied probability of 81.98% of making the Final Four, according to our odds converter, before they eventually reached the semifinal and won it all.

Who was in last year's Final Four?

The UConn Huskies, Purdue Boilermakers, Alabama Crimson Tide, and NC State Wolfpack reached the Final Four of the NCAA Tournament after winning their respective regions in March Madness.  

UConn and Purdue advanced to meet in the national championship game on Monday, April 8. The Huskies won that game 75-60 to secure back-to-back titles.

Where was the Final Four played last year?

The 2024 Final Four and national championship game were held at State Farm Stadium in Phoenix, Ariz.

March Madness betting odds pages

March Madness OddsMarch Madness PredictionsFinal Four OddsMarch Madness MVP Odds
March Madness Prop BetsMarch Madness Upset PicksMarch Madness Bracket GuideMarch Madness Bracket Predictions
March Madness Bracket ChallengeMarch Madness betting promos

👑 Best March Madness betting sites

Ready to place your March Madness bets? Check out the best March Madness betting promos from our best March Madness betting sites, as determined by our expert team at Sportsbook Review.

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Written By:
Rob Paul
Rob is a Publishing Editor at Sportsbook Review. He’s been with the team since early 2024, with this being his first full-time role in the sports betting industry. Before joining SportsbookReview.com, he contributed to various sports outlets, including FanSided and Pro Football Network. During that period, he spent five years working full-time as a local community journalist, after attending Durham College for journalism and Wilfrid Laurier University for history. He previously hosted an NFL draft and college football-focused podcast where he had the opportunity to interact with future NFL players such as Maxx Crosby and Quinn Meinerz. Rob has spent multiple years working as a freelance podcast producer for numerous sports-related podcasts while making guest appearances on several college football shows. He’s also made guest appearances on SportsTalk Mississippi on several occasions to talk all things NFL draft. Rob values the way sports betting acts as a catalyst for telling stories and growing interest in certain sports, particularly FCS football, WNBA, and mid-major college basketball. He’s always been drawn to the more obscure teams and conferences in major college sports, but most of all, Rob loves using stats to find the best player props to back.