MLB Odds & Schedule Today: Who Plays Baseball on Opening Day?

Andrew Brennan

Last Updated: March 27, 2025 12:13 PM EDT • 5 min 40 sec read. Twitter link Google News Link

MLB Odds & Schedule Today: MLB Moneyline Odds, Full Schedule for Opening Day — Pictured: Philadelphia Phillies first baseman Bryce Harper looks on against the New York Yankees. Photo by Kim Klement Neitzel via Imagn Images.

Opening Day is finally here, as almost every MLB team will play their first regular-season game today.

There will be no shortage of star power in action around the league today, and we're treated to one of the game's brightest - and biggest - stars right away, as Aaron Judge and the New York Yankees get the day going against the Milwaukee Brewers.

Headlining our MLB moneyline odds for Opening Day, though, are the World Series odds favorites, the Los Angeles Dodgers. Shohei Ohtani and Co. will host reigning AL Cy Young winner Tarik Skubal and his Detroit Tigers.

Closing out the Opening Day schedule is a matchup between two teams looking to climb the AL West standings this year, as the Athletics will visit the Seattle Mariners.

📅 MLB schedule and odds today: Opening Day

Here is the complete schedule and MLB moneyline odds for Opening Day. You can also check out our MLB player prop odds tool for the latest MLB odds at the best legal sportsbooks in your region.

MLB picks for Opening Day

⚾ When do Brewers vs. Yankees play today?

📅 Date: Thursday, March 27
🕗 Time: 3:05 p.m. ET
📍 Location: Yankee Stadium (The Bronx)
📺 TV: ESPN
💻 Streaming: ESPN+, MLB TV
💪 Favorite: Yankees (-155 via DraftKings)
👀 Player to watch: Will reigning home run king and MLB MVP odds favorite Aaron Judge go deep on Opening Day?

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⚾ When do Orioles vs. Blue Jays play today?

📅 Date: Thursday, March 27
🕗 Time: 3:07 p.m. ET
📍 Location: Rogers Centre (Toronto)
📺 TV: MASN2, Sportsnet
💻 Streaming: MLB TV
💪 Favorite: Orioles (-120 via FanDuel)
👀 Player to watch: Will Vladimir Guerrero Jr. get off to a hot start, encouraging the Blue Jays to pay him what he wants? Or is he perhaps auditioning for his new team? (Check out our Vladimir Guerrero Jr. next team odds.)

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⚾ When do Phillies vs. Nationals play today?

📅 Date: Thursday, March 27
🕗 Time: 4:05 p.m. ET
📍 Location: Nationals Park (Washington)
📺 TV: NBC Sports Philadelphia, MASN
💻 Streaming: MLB TV
💪 Favorite: Phillies (-175 via BetMGM)
👀 Player to watch: Will Cy Young odds contender Zack Wheeler dominate one of the league's weaker teams in his season debut?

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⚾ When do Red Sox vs. Rangers play today?

📅 Date: Thursday, March 27
🕗 Time: 4:05 p.m. ET
📍 Location: Globe Life Field (Arlington, Texas)
📺 TV: NESN
💻 Streaming: Victory+, MLB TV
💪 Favorite: Red Sox (-120 via Caesars)
👀 Player to watch: Alex Bregman plays his first game for his new team, and it comes in the state where he's spent his entire career.

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⚾ When do Pirates vs. Marlins play today?

📅 Date: Thursday, March 27
🕗 Time: 4:10 p.m. ET
📍 Location: loanDepot park (Miami)
📺 TV: FanDuel Sports Network Florida, SportsNet Pittsburgh
💻 Streaming: MLB TV
💪 Favorite: Pirates (-150 via bet365)
👀 Player to watch: It's the Pittsburgh Pirates on Opening Day, so all eyes will be on their ace and arguably the best pitcher in baseball: Paul Skenes. The Over on 6.5 strikeouts (-175) for him is the player prop generating the most tickets at BetMGM.

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⚾ When do Giants vs. Reds play today?

📅 Date: Thursday, March 27
🕗 Time: 4:10 p.m. ET
📍 Location: Great American Ball Park (Cincinnati)
📺 TV: NBC Sports Bay Area, FanDuel Sports Network Ohio
💻 Streaming: MLB TV
💪 Favorite: Reds (-112 via DraftKings)
👀 Player to watch: Reigning stolen base king and NL MVP dark horse Elly De La Cruz will try to run on one of baseball's best arms behind the plate, Patrick Bailey.

⚾ When do Angels vs. White Sox play today?

📅 Date: Thursday, March 27
🕗 Time: 4:10 p.m. ET
📍 Location: Rate Field (Chicago)
📺 TV: Chicago Sports Network
💻 Streaming: MLB TV
💪 Favorite: Angels (-158 via FanDuel)
👀 Player to watch: Who knows how many games we'll be able to watch Mike Trout play in this year, so let's appreciate one of baseball's best players ever while he's healthy.

⚾ When do Guardians vs. Royals play today?

📅 Date: Thursday, March 27
🕗 Time: 4:10 p.m. ET
📍 Location: Kauffman Stadium (Kansas City)
📺 TV: CLEG, FanDuel Sports Network Kansas City
💻 Streaming: MLB TV
💪 Favorite: Royals (-130 via BetMGM)
👀 Player to watch: Bobby Witt Jr. made his presence known in the AL MVP race last year, pushing Judge right to the end. How will he kick off his campaign?

⚾ When do Mets vs. Astros play today?

📅 Date: Thursday, March 27
🕗 Time: 4:10 p.m. ET
📍 Location: Daikin Park (Houston)
📺 TV: SNY, Space City Home Network
💻 Streaming: MLB TV
💪 Favorite: Astros (-130 via Caesars)
👀 Player to watch: Mets outfielder Juan Soto makes his regular-season debut with his third team in three years after a career-best campaign with the Yankees.

⚾ When do Braves vs. Padres play today?

📅 Date: Thursday, March 27
🕗 Time: 4:10 p.m. ET
📍 Location: Petco Park (San Diego)
📺 TV: Gray Media
💻 Streaming: MLB TV
💪 Favorite: Braves (-130 via bet365)
👀 Player to watch: Reigning NL Cy Young winner Chris Sale looks to get his World Series-contender Braves a win on Opening Day.

⚾ When do Twins vs. Cardinals play today?

📅 Date: Thursday, March 27
🕗 Time: 4:15 p.m. ET
📍 Location: Busch Stadium (St. Louis)
📺 TV: FanDuel Sports Network Midwest
💻 Streaming: Twins.TV, MLB TV
💪 Favorite: Pick'em via DraftKings
👀 Player to watch: There isn't a ton of star power on either of these teams, but I'm keeping an eye on Masyn Winn, one of the best young infielders in baseball.

⚾ When do Tigers vs. Dodgers play today?

📅 Date: Thursday, March 27
🕗 Time: 7 p.m. ET
📍 Location: Dodger Stadium (Los Angeles)
📺 TV: ESPN
💻 Streaming: ESPN+, MLB TV
💪 Favorite: Dodgers (-164 via FanDuel)
👀 Player to watch: Shohei Ohtani, Freddie Freeman, Mookie Betts, Blake Snell, Tarik Skubal - take your pick of which superstar you're most interested in tracking for this exciting Opening Day showdown.

⚾ When do Cubs vs. Diamondbacks play today?

📅 Date: Thursday, March 27
🕗 Time: 10:10 p.m. ET
📍 Location: Chase Field (Phoenix)
📺 TV: Marquee Sports Network
💻 Streaming: DBacks.TV, MLB TV
💪 Favorite: Diamondbacks (-140 via BetMGM)
👀 Player to watch: Following a quiet Tokyo Series, Cubs offseason addition Kyle Tucker will hope to rebound now that he's back stateside.

⚾ When do Athletics vs. Mariners play today?

📅 Date: Thursday, March 27
🕗 Time: 10:10 p.m. ET
📍 Location: T-Mobile Park (Seattle)
📺 TV: NBC Sports California, Root Sports Northwest
💻 Streaming: MLB TV
💪 Favorite: Mariners (-170 via Caesars)
👀 Player to watch: The Mariners quietly feature a ton of star power, including perennial AL MVP contender Julio Rodriguez. They failed to put it all together in 2024, but can they bounce back this season?

🏟️ MLB betting odds pages

World Series Odds	MLB MVP Odds	MLB Cy Young Award Odds
World Series MVP Odds	MLB Rookie of the Year Odds	MLB Win Totals

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Written By:
Andrew Brennan

Andrew Brennan is a publishing editor for Sportsbook Review. He also heads the website’s MLB coverage, from the various futures markets to daily picks. Andrew believes a math-based approach is the best way to enjoy long-term success in sports betting, and he’s spent the better part of the last year fine-tuning his own process for MLB, NBA, and NFL picks. Andrew uses eight different sportsbooks to find the best odds available and various projection models to gather as much information as he can. His most used sportsbooks are bet365, FanDuel, and theScore Bet. When it comes to daily projection models, he regularly references NumberFire across all sports, as it’s one of the best free tools available. In terms of which daily markets Andrew attacks, he almost exclusively bets on pitcher strikeouts for baseball. When the winter rolls around, you’ll see him providing more variety when it comes to the NBA (points, assists, rebounds) and NFL (almost any offensive-based player prop). He used these tools to go +150 units in 2023. Andrew is also a passionate fantasy sports player. He’s played fantasy football, fantasy Premier League, and fantasy baseball for the last decade. He graduated from Durham College with his diploma in journalism after earning his degree in law from Carleton University. He’s worked in sports media since early 2017, first contributing at FanSided before moving to theScore. He joined SBR in 2022.