Best Home Run Predictions Today: MLB Odds, Picks & Prop Bets for Saturday, May 17

There's a plethora of hot bats to pick from to go yard, but our best home run predictions today are locked in on several of the biggest stars in the sport, including Shohei Ohtani.

💰 Best MLB home run predictions & odds today: May 17

Here are my best MLB home run predictions and odds today with my pick confidence based on a 1-to-5-star scale. You can also check out our MLB player prop odds tool for the latest MLB odds at the best legal sportsbooks in your region.  

🧨 Gunnar Henderson to hit a home run (+330 via DraftKings) vs. Nationals ⭐⭐
🧨 Alex Bregman to hit a home run (+330 via FanDuel) vs. Braves ⭐⭐⭐
🧨 Fernando Tatis Jr. to hit a home run (+350 via bet365) vs. Mariners ⭐⭐⭐
🧨 Shohei Ohtani to hit a home run (+200 via FanDuel) vs. Angels ⭐⭐⭐⭐

💣 Home run predictions today: MLB expert picks & prop bets

Here's a breakdown of my best home run prop predictions and expert picks today. Check out the rest of our MLB picks along with our guide on how to bet on MLB.  

⚾ Gunnar Henderson (Orioles) to hit a home run ⭐⭐

The Baltimore Orioles may have just fired manager Brandon Hyde after an ugly start to the season, but that shouldn't stop Henderson from putting on a show against the Washington Nationals. With the Nats marching Jake Irvin out onto the mound, Henderson is in perfect position to hit a bomb.

Irvin has given up the sixth-most home runs in the majors (10) and loves his curveball (38.9% of the time) and four-seamer (28.1%), per Baseball Savant. Last season, Henderson smeared curves to the tune of a .771 SLG, and this season he's gotten after four-seamers with a .345 xBA and .505 xSLG to go with a 72.5% hard hit rate.

Best odds: +330 via DraftKings (bet $10 to win $33)

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📊 Nationals vs. Orioles home run odds

⚾ Alex Bregman (Red Sox) to hit a home run ⭐⭐⭐

Despite both the Atlanta Braves and Boston Red Sox sliding down the World Series odds after iffy starts, this matchup is still worth tuning into to see a handful of heavy hitters. One such bat is Bregman, who sits 10th in MLB in dingers (11) and should give Grant Holmes all types of issues.

Holmes has been beaten up on this year, giving up the 11th-most home runs in baseball (9), and he doesn't stack up well against Bregman. The Braves' righty uses his four-seamer 39.9% of the time and his slider 31.7% of the time. Bregman is hammering both with a .526 SLG off four-seamers and a .621 SLG off sliders.

Best odds: +330 via FanDuel (bet $10 to win $33)

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📊 Braves vs. Red Sox home run odds

⚾ Fernando Tatis Jr. (Padres) to hit a home run ⭐⭐⭐

No pitcher wants to see Tatis Jr. stepping up to bat, especially not Seattle Mariners righty Emerson Hancock. Hancock has given up six homers across six starts and brings a 6.91 ERA to the mound - that's not the most awe-inspiring number to see when facing one of baseball's premier home run hitters.

With Tatis sitting 10th in MLB in home runs (11), he should be able to add to his total today against a pitcher who predominantly uses his sinker (42.9%). Opponents are thrashing his sinker with a .375 average and .554 SLG against it, while the 26-year-old Tatis should only add to that with his .367 average against sliders this year.

Best odds: +350 via bet365 (bet $10 to win $35)

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📊 Mariners vs. Padres home run odds

⚾ Shohei Ohtani (Dodgers) to hit a home run ⭐⭐⭐⭐

The MLB MVP odds leader in the NL has an ideal opportunity to send a baseball to the moon tonight with the Los Angeles Angels sending Tyler Anderson to the mound to try and slow Ohtani's tear down. The Dodgers DH leads baseball in home runs (16),  while Anderson has given up seven long balls already this season.

The Angels' lefty lives and dies by his four-seamer (41%) and changeup (34.7%), and Ohtani couldn't be happier with that, given how he smashes both pitches. This season, Ohtani has a .368 xBA, .833 xSLG, and 72.3% hard hit rate against four-seamers, and a .620 xSLG and 66.7% hard hit rate against changeups. Enjoy watching the best baseball player on Earth hit a pitch into space.

Best odds: +200 via FanDuel (bet $10 to win $20)

📊 Angels vs. Dodgers home run odds

💰Best MLB home run parlay picks

Here is our best MLB home run parlay for Saturday's baseball action; use our parlay calculator to get the best odds for any parlay.

💣 Gunnar Henderson to hit a home run (+255)
💣 Alex Bregman to hit a home run (+330)
💣 Fernando Tatis Jr. to hit a home run (+320)
💣 Shohei Ohtani to hit a home run (+200)

🚀 Best parlay odds: +19133 via FanDuel ($10 to win $1,913.30)

💵 Best MLB betting sites

Want to bet on baseball? Check out the best MLB betting sites and best sportsbook promos for today's games:

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