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MLB Preseason Home Run Parlay: Bet These 5 Sluggers at +4114 Odds Ahead of Opening Day

C Jackson Cowart

Last Updated: March 27, 2025 12:23 PM EDT • 5 min 5 sec read.

MLB Preseason Home Run Parlay
Pictured: Toronto Blue Jays first base Vladimir Guerrero Jr. (27) singles against the Tampa Bay Rays. Photo by Nathan Ray Seebeck / Imagn Images.

Opening Day is here, which means the clock is winding down on making those MLB preseason futures bets that keep you locked in through the entire 162-game season.

Inspired by a fun post from Covers betting expert (and former SBR analyst) Jon Metler, we're cooking up our own MLB home run parlay for the regular season with +4114 odds turning a $10 bet into a $411.40 profit if we cash in on these five hitters.

👉 Want more preseason action? Check out all of our MLB preseason awards predictions along with our MLB preseason AI predictions for every division and major award.

💪 Best MLB preseason home run futures bets entering Opening Day

Here's a look at five of my favorite MLB preseason home run futures bets entering Opening Day. All of these are available via FanDuel, which allows you to parlay together your HR futures if you bet into their alt-total markets (as we are below).

⚾ Vladimir Guerrero Jr. to hit 30+ HRs

Every good parlay needs an anchor leg, and we're hitching our wagon to Vladimir Guerrero Jr. ahead of the first official contract year of his MLB career.

Dating back to his 48-HR season in 2021, Guerrero has cleared this mark in three of his last four seasons. The lone exception came in 2023, when he won the Home Run Derby and still hit 26 dingers despite a career-worst .277 BABIP and subpar .264 average.

The four-time All-Star shook that off last season by hitting .323 with 30 home runs behind a 54.9% hard-hit rate - his best mark since that MVP-worthy season in 2021. If Vladdy wants to cash in on a $500 million contract ahead of next season, he should clear this mark with ease.

📊 Odds to hit 30+ home runs: -178 via FanDuel (64.03% implied probability)

⚾ Mark Vientos to hit 30+ HRs

Mark Vientos isn't quite a household name outside of Queens, but that might not remain the case for long after the 26-year-old slugger exploded onto the scene in 2024 - hitting 27 home runs in just 111 games with a .516 slugging percentage and .837 OPS. Those would have ranked in the top 20 among qualified hitters had he played more.

The Mets third baseman added five more home runs in 13 playoff games for good measure, showcasing the same plate discipline and strong barrel rate that helped fuel his breakout in the first place. There's a reason he's considered the potential long-term answer at the hot corner ... and it's not because of his defense.

You might be skeptical of the small sample size, but the eye test and advanced metrics both point toward Vientos as a legit slugger. So do his -150 odds for this bet at DraftKings, which imply a 60% hit rate for something that we can target at near-even odds at FanDuel.

📊 Odds to hit 30+ home runs: -102 via FanDuel (50.50% implied probability)

⚾ Cal Raleigh to hit 30+ HRs

Even after the Mariners signed him to an extension worth over $100 million earlier this week, Cal Raleigh remains perhaps the most underrated catcher in baseball. He's led the position with a combined 91 home runs over the last three years, and he's blasted 30 or more in each of the last two seasons. (He had 27 home runs in just 119 games in 2022.)

Raleigh should get every opportunity to rake in the heart of Seattle's lineup even if he doesn't make much contact - he's hit .222 over the last three years but still nearly ranks in the top 50 with a .475 slugging percentage in that stretch. It's hard to ignore these plus-money odds on a third straight season with 30-plus homers.

📊 Odds to hit 30+ home runs: +104 via FanDuel (49.02% implied probability)

⚾ Jake Burger to hit 30+ HRs

Despite having one of the best names in baseball, Jake Burger remains supremely underrated for someone who ranks among the league leaders in bat speed and barrel rate over the last two seasons.

He hit 34 home runs in 2023 and knocked out 29 more in 2024 in four fewer games, and he'll be an everyday starter for the Rangers after they traded for him to be their top first baseman in 2025. Four of the six main projection models at Fangraphs have Burger hitting 30 home runs, and the ones that don't have him playing fewer than 140 games.

Given that he's dealing at -105 via DraftKings to hit 30 homers - which implies a better than 50% chance of him doing so - I love the value we're getting on Burger's odds at FanDuel to boost our HR parlay.

📊 Odds to hit 30+ home runs: +142 via FanDuel (41.32% implied probability)

⚾ Oneil Cruz to hit 30+ HRs

Here's a list of every MLB player with a better average exit velocity than Oneil Cruz: Shohei Ohtani and Aaron Judge. That's it. Only Giancarlo Stanton has a better average bat speed, and none featured a longer average home run distance (422 feet) than the Pirates' young star last season.

So why is he dealing at such long odds to eclipse 30 home runs? Because he struck out on 30.2% of his plate appearances last year and benefitted from a .347 BABIP. Some of that is a result of how freaking hard he hits the ball, which is how he hit 21 home runs in 146 games last year despite nearly half of his balls in play hitting the infield dirt.

If the risk is too high, you can parlay the other four picks together at +1426 odds, which would turn a winning $10 bet into a $142.60 profit. I'm willing to bet on the talent here and buy Cruz at a relative dip ahead of what should be a monster campaign - while nearly tripling our potential return by adding him to this parlay.

📊 Odds to hit 30+ home runs: +176 via FanDuel (36.23% implied probability)

🚀 Best MLB preseason HR parlay

If you bet on the five players above to each hit 30 home runs, you can combine those five picks into one preseason parlay at FanDuel with +4114 odds, which would turn a $10 bet into a $411.40 profit if all five players hit 30 HRs or more in 2025.

⚾ Vladimir Guerrero Jr. to hit 30+ HRs (-178)
⚾ Mark Vientos to hit 30+ HRs (-102)
⚾ Cal Raleigh to hit 30+ HRs (+104)
⚾ Jake Burger to hit 30+ HRs (+142)
⚾ Oneil Cruz to hit 30+ HRs (+176)

💰 Wager $10 → Win $411.40
💰 Wager $50 → Win $2,057.00

👉 Want to build more MLB parlays? Use our parlay calculator to find the best odds across our best sports betting sites.

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Written By:
C Jackson Cowart
C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.