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March Madness Final Four Odds & Updated Betting Lines: Our Picks & Predictions Ahead of Sweet 16

Andrew Reid

Last Updated: March 27, 2025 9:45 AM EDT • 3 min 42 sec read.

Latest March Madness Final Four Odds: Our Picks & Predictions Ahead of Sweet 16
Pictured: Houston Cougars guard Emanuel Sharp reacts after a play against the Gonzaga Bulldogs during the second half at Intrust Bank Arena. Photo by Nick Tre. Smith via Imagn Images.

The madness of March has been limited thus far. Ahead of the Sweet 16, we still have four No. 1 seeds, three No. 2 seeds, two No. 3 seeds, and three No. 4 seeds. Not a lot of upsets through the first two rounds, to say the least.

That doesn't mean that'll continue, though, and we offered our March Madness long shot rankings ahead of the Sweet 16, which concludes today.

But the leap to the top of the Final Four odds is still a big one, and we should get some excellent NCAA Tournament basketball with so many top schools still in the running. 

Let's have a look at the latest March Madness Final Four odds.

4️⃣ Final Four odds 2025

Our 2025 Final Four odds via BetMGM. Throughout the NCAA Tournament, visit Sportsbook Review to get the best college basketball prop bets today.

  • Duke (-182)
  • Auburn (-133)
  • Florida (-128)
  • Houston (-125)
  • Tennessee (+240)
  • Michigan State (+260)
  • Texas Tech (+300)
  • Alabama (+360)
  • Maryland (+450)
  • Kentucky (+650)
  • Arizona (+700)
  • Michigan (+700)
  • Ole Miss (+700)
  • Purdue (+700)
  • BYU (+700)
  • Arkansas (+900)
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🏅Final four favorites

It's happened just four times in history according to the March Madness stats & records: all four No. 1 seeds reaching the Final Four. The oddsmakers would have you believe that it's not beyond the pale to happen this year. 

All four top seeds lead the way as favorites: No. 1 Duke (-182), No. 1 Auburn (-133), No. 1 Florida (-128), and No. 1 Houston (-125) are all trading at minus money to reach the penultimate stage of the tournament.

Currently, Duke is getting both the highest ticket percentage (13.2%) and highest handle (38.3%) to win the NCAA Tournament at BetMGM. Florida is in second (9.1% of the tickets and 12.7% of the handle).

Looking at the March Madness Sweet 16 schedule and odds, we see Houston has the toughest path (having to face a No. 2 or 3 seed if it advances to the Elite Eight) while Florida arguably has the easiest path if it advances (facing a No. 3 or No. 10).

  • If No. 1 Florida beats No. 4 Maryland in the West Region, it'll face No. 3 Texas Tech or No. 10 Arkansas in the Elite Eight.
  • If No. 1 Auburn beats No. 5 Michigan in the South Region, it'll face No. 2 Michigan State or No. 6 Ole Miss in the Elite Eight.
  • If No. 1 Duke beats No. 4 Arizona in the East Region, it'll face No. 2 Alabama or No. 6 BYU in the Elite Eight.
  • If No. 1 Houston beats No. 4 Purdue in the Midwest Region, it'll face No. Tennessee or No. 3 Kentucky

Below, we'll look at the odds to win each region. 

🌎 Odds to win each region

East Region

Unsurprisingly, the East runs through Duke. The Blue Devils are the biggest favorites to reach the final four and the consensus betting favorites to win the national championship per the March Madness odds.  

Sweet 16 matchups: 

  • No. 1 Duke vs. No. 4 Arizona, Thursday, March 27 at 9:39 p.m. ET (CBS)
  • No. 2 Alabama vs. No. 6 BYU, Thursday, March 27 at 7:09 p.m. ET (CBS)

West Region

Florida remains the class of the West region and is a top challenger to Duke to win the title. The Gators have arguably the easiest path to the Final Four, provided they face a No. 3 or No. 10 seed if they advance to the Elite Eight. 

Sweet 16 matchups:

  • No. 1 Florida vs. No. 4 Maryland, Thursday, March 27 at 7:39 p.m. ET (TBS/truTV)
  • No. 3 Texas Tech vs. No. 10 Arkansas, Thursday, March 27 at 10:09 p.m. ET (TBS/truTV)

South Region

Auburn spent a good deal of the season as the favorite to cut down the nets but has slipped following a number of uninspired performances toward the end of the season and in the SEC Tournament.

Sweet 16 matchups: 

  • No. 1 Auburn vs. No. 5 Michigan, Friday, March 28, 9:39 p.m. ET (CBS)
  • No. 2 Michigan State vs. No. 6 Ole Miss, Friday, March 28, 7:09 p.m. ET (CBS)

Midwest Region

Houston has the most difficult path to reach the final four, having to knock off a No. 4 seed just to reach the Elite Eight and then facing the winner of a No. 2-3 game. 

Sweet 16 matchups: 

  • No. 1 Houston vs. No. 4 Purdue, Friday, March 28 at 10:09 p.m. ET (TBS/truTV)
  • No. 2 Tennessee vs. No. 3 Kentucky, Friday, March 28 at 7:39 p.m. ET (TBS/truTV)

🧠 Sweet 16 expert picks

🆚 Sweet 16 game predictions

💰 March Madness betting odds pages

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👑 Best March Madness betting sites

Ready to place your March Madness bets? Check out the best March Madness betting promos from our best March Madness betting sites, as determined by our expert team at Sportsbook Review.

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Written By:
Andrew Reid
Andrew is a Publishing Editor at Sportsbook Review. He graduated from Acadia University with a degree in Kinesiology, working as a personal trainer and in injury rehab, and then attended the College of Sports Media in Toronto to attain a diploma in Radio and Television Sports Broadcasting. Andrew has been involved in the sports betting and fantasy sports space since joining the FNTSY Sports Network in 2014, where he worked as a producer, director, and occasional on-air talent on various shows focusing on sports betting and DFS content. Prior to joining SBR, he spent multiple years with the USA Today Network as an editor and writer. Living in Newfoundland, Andrew frequents grey market sportsbooks, but in the past, when he's lived in regulated areas, he's become well-versed with all of our best sportsbooks. As strictly a casual bettor, he enjoys making touchdown parlays with friends (bro-lays), sweating out golf cut parlays during majors, playing same-game parlays for fun, and chasing long-shot bets. He also enjoys using sportsbooks that have solid iGaming and casino platforms. As the old guy on staff, he has an affinity for industry news, which confuses some, but shh ... quiet ... the news is on.