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LSU vs. Florida State Prediction
Pictured: LSU's Flau'Jae Johnson against San Diego State in the first round of the NCAA Tournament. Photo by Scott Clause via Imagn Images.

The No. 3 LSU Tigers (29-5) face the No. 6 Florida State Seminoles (24-8) in a second-round showdown on Monday at 6 p.m. ET (ESPN) at the Pete Maravich Assembly Center in Baton Rouge, La.

LSU enters as an 11.5-point favorite to reach the Sweet 16 in the Spokane 1 Region of the women's March Madness bracket. Our LSU vs. Florida State prediction, odds, and preview back the Tigers to take care of business as part of our women’s March Madness predictions.

🏀 LSU vs. Florida State prediction & picks for Monday

Here are my best LSU vs. Florida State predictions for the first round of the NCAA Tournament; use our parlay calculator to get the best odds for any same-game parlay:

✅ Against the spread pick: LSU -11.5 (-110 via BetMGM) vs. Florida State ⭐⭐⭐
🔥 Best player prop bet: Flau’Jae Johnson 20-plus points (
+108 via FanDuel) ⭐⭐⭐
🎯 Exact score prediction: LSU 92, Florida State 78 

👉 Want more March Madness action? Check out the rest of our college basketball picks for both the men's and women's NCAA tournament.

📈 LSU vs. Florida State betting action 

The below betting action is via BetMGM.

  • Florida State +425 is the second-most bet underdog to win in the women's NCAA Tournament today

🏆 Best LSU vs. Florida State pick, player prop bet & score prediction

Our NEW college basketball player prop odds tool can help you find the best odds for any March Madness market across legal sportsbooks in your area!

✅ LSU to cover the spread: -11.5 ⭐⭐⭐

There was no sign of rust in Flau’Jae Johnson’s first game back for LSU. She scored 22 points in as many minutes, leading the Tigers to a 103-48 victory over San Diego State.

This game has potential track meet written all over it, with the total trading at 170.5. The Tigers are more than comfortable with that, ranking sixth in the nation with an average of 85 points per game.

This spread moved from 10.5 to 11.5 Sunday morning, indicating that bettors are laying the points with LSU, who are among the women's March Madness odds contenders.

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📊 Best odds: -110 via BetMGM ($10 to win $9.09)

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🔥 Flau’Jae Johnson 20-plus points ⭐⭐⭐

I was worried that Flau’Jae Johnson would be a bit rusty in her first game back after missing the SEC tournament and regular-season finale. However, the 22-point performance on 9-of-15 shooting showed that Johnson is fully back for the NCAA Tournament.

This game could be a track between two teams that want to score (and quickly), suggesting there is value in the plus-money price on Johnson to record 20 or more points. 

Johnson averaged 19 points per game this season, but it’s easier to project a mark in the 20s with Florida State’s defense being particularly vulnerable. Of our best sports betting sites, FanDuel is the place to lock in this pick. 

📊 Best odds: +108 via FanDuel ($10 to win $10.80)

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🎯 Score prediction: LSU 92, Florida State 78

HerHoopStats projects a 92-80 win for LSU on Monday. A high-scoring game increases the variance, but I expect the Tigers to roll in a potential track meet. Exact score odds aren’t available at DraftKings as of this writing, though it will likely be between +16000 and +17000.

🤖 LSU vs. Florida State AI prediction

For entertainment purposes, we asked ChatGPT to analyze historical trends and live NCAA Tournament stats before predicting the winner and exact score for Higher Seed vs. Lower Seed. Our AI prediction projects a final score of LSU 86, Florida State 75.

🖥️ AI score prediction: LSU 86, Florida State 75

  • LSU is red-hot, coming off a 103–48 win over San Diego State. The Tigers’ scoring depth, physicality, and home-court advantage in Baton Rouge make them tough to beat. 
  • Florida State is dangerous with Ta’Niya Latson, who averages nearly 25 points per game. The Seminoles play fast and score efficiently, but their defense is suspect—especially against powerhouse teams.
  • This could be a high-scoring shootout. Both teams prefer uptempo play, but LSU has the edge in rebounding and bench production.

🤔 Betting takeaway: ChatGPT's AI prediction would mean Florida State covering the spread (+11.5) and a total of Under 170.5 points. ChatGPT is not a dedicated sports betting model, but it can identify data that March Madness bettors might overlook.

📊 Live LSU vs. Florida State odds

Follow the latest women's March Madness odds for the NCAA Tournament.

🔢 LSU vs. Florida State opening odds

  • Spread: LSU -10.5 (-110) | Florida State +10.5 (-110)
  • Moneyline: LSU -625 | Florida State +450
  • Over/Under: Over 170.5 (-110) | Under 170.5 (-110)

📺 How to watch LSU vs. Florida State: Women's March Madness

📅 Date: Monday, March 24
🕗 Time: 6 p.m. ET
📍 Location: Pete Maravich Assembly Center (Baton Rouge, LA)
📺 TV: ESPN
💻 Streaming: March Madness Live

💰 March Madness betting odds pages

👑 Best March Madness betting sites

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