March Madness Odds Entering Final Four: Duke, Florida Favored to Win NCAA Tournament

C Jackson Cowart

Last Updated: March 30, 2025 8:12 PM EDT • 3 min 30 sec read. Twitter link Google News Link

March Madness Odds: Duke, Florida Enter Final Four as NCAA Tournament Favorites — Pictured: Duke Blue Devils guard Tyrese Proctor (5) talks with forward Cooper Flagg (2) in the 2025 NCAA Tournament. Photo by Vincent Carchietta / Imagn Images.

For the second time in March Madness history, all four No. 1 seeds have advanced to the Final Four of the NCAA Tournament after Houston and Auburn punched their tickets to the semifinals on Sunday.

Duke remains the March Madness odds favorite with +110 odds to win it all after a dominant four-game run to the Final Four. Florida sits right behind the title favorite Blue Devils after rallying to beat Texas Tech in the Elite Eight.

Here's a breakdown of the latest March Madness odds and favorites to cut down the nets in San Antonio and win the 2025 NCAA Tournament.

🏆 Updated March Madness odds & favorites to win 2025 NCAA Tournament

💪 Final Four favorites & odds to win NCAA Tournament

😈 No. 1 Duke (+110 via DraftKings)

🆚 Final Four opponent: No. 1 Houston
📊 Best ML odds: -205 via DraftKings

The Blue Devils entered the tournament with five of the best players in March Madness, and they've relied on that depth and star power en route to a seemingly inevitable Final Four run for our expert Rob Paul's predicted March Madness champion.

Jon Scheyer's group will face a tough opponent in the Final Four in Houston, which bludgeoned 2-seed Tennessee in the Elite Eight and boasts the best defensive efficiency in the country. Duke's offense is the top unit nationally, too, setting up a true clash of titans in Saturday's second matchup at 8:49 p.m. ET.

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🐊 No. 1 Florida (+300 via BetMGM)

🆚 Final Four opponent: No. 1 Auburn
📊 Best ML odds: -142 via DraftKings

The Gators were the hottest team in the country entering the NCAA Tournament, and they played with fire in the Elite Eight before erasing a late deficit to beat Texas Tech and set up this SEC showdown with Auburn in the Final Four on Saturday at 6:09 p.m. ET.

Florida won the only meeting between these two back in early February, a 90-81 road victory for the Gators, and the Tigers could be in worse shape this time around if Johni Broome isn't at full strength after his injury in the Elite Eight.

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🐶 Final Four underdogs & odds to win NCAA Tournament

🐯 No. 1 Auburn (+650 via bet365)

🆚 Final Four opponent: No. 1 Florida
📊 Best ML odds: +126 via FanDuel

Is Broome fully healthy heading into the title game? And if so, is that enough to change the outcome this time around against one of the only teams to beat Auburn in the regular season?

We've had our doubts about the Tigers all tournament long, but Bruce Pearl and Co. keep winning, so it's hard not to be enticed by these long odds on the field's No. 1 overall seed - especially if Broome, who finished with 25 points and 14 rebounds in the Elite Eight, is ready to roll by Saturday.

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🛑 No. 1 Houston (+700 via bet365)

🆚 Final Four opponent: No. 1 Duke
📊 Best ML odds: +172 via FanDuel

It's a tough draw for Houston, which is the second-best team in the country per KenPom but enters the Final Four as the biggest long shot because of who's on the other side.

If anyone can try to contain Cooper Flagg, Kon Knueppel, Tyrese Proctor, and friends, it'd be Houston and its top-ranked defense in the country. The Cougars are also prolific from long range and haven't lost a game since Feb. 1 - this isn't your typical long shot.

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Written By:
C Jackson Cowart

C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.