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March Madness Sweet 16 Predictions: Our Expert Picks for Every NCAA Tournament Game This Week

Andrew Reid

Last Updated: March 28, 2025 8:02 AM EDT • 2 min 18 sec read.

March Madness Sweet 16 Predictions: Our Expert Picks for Every NCAA Tournament Game
Pictured: Mississippi Rebels guard Dre Davis dunks against Iowa State Cyclones in the second round of the NCAA Tournament. Photo by Benny Sieu via Imagn Images.

The madness picks up again today with the conclusion of the NCAA Tournament Sweet 16. While the opening rounds featured many favorites getting through, that doesn't mean we can't still see plenty of March Madness as we head through the tournament's final rounds.

Ahead of the upcoming four games across the evening, we take a look at our March Madness Sweet 16 predictions with expert picks for every game.

We've also provided a look at the full March Madness Sweet 16 schedule and odds.

🗓️ Today's NCAA Tournament schedule

  • No. 2 Michigan State vs. No. 6 Ole Miss, 7:09 p.m. ET (CBS), South Region
  • No. 2 Tennessee vs. No. 3 Kentucky, 7:39 p.m. ET (TBS/truTV), Midwest Region
  • No. 1 Auburn vs. No. 5 Michigan, 9:39 p.m. ET (CBS), South Region
  • No. 1 Houston vs. No. 4 Purdue, 10:09 p.m. ET (TBS/truTV), Midwest Region

  👉 See all of the college basketball odds from our best March Madness betting sites.

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🏀 Sweet 16 predictions & best bets for today

🎯 No. 2 Michigan State vs. No. 6 Ole Miss, 7:09 p.m. ET (CBS), South Region

Expert pick (Philip Wood): Michigan State -3.5 (-105 via BetMGM) vs. Ole Miss ⭐⭐⭐⭐

🎯 No. 2 Tennessee vs. No. 3 Kentucky, 7:39 p.m. ET (TBS/truTV), Midwest Region

Expert pick (Brenden Schaeffer): Kentucky +4.5 (-115 via FanDuel) vs. Tennessee ⭐⭐⭐⭐

🎯 No. 1 Auburn vs. No. 5 Michigan, 9:39 p.m. ET (CBS), South Region

Expert pick (Philip Wood): Michigan +8.5 (-105 via BetMGM) vs. Auburn ⭐⭐⭐

March Madness Sweet 16 Predictions: Our Expert Picks for Every NCAA Tournament Game
Pictured: Auburn Tigers guard Tahaad Pettiford celebrates during the second half against the Creighton Bluejays in the second round of the NCAA Tournament. Photo by Aaron Doster via Imagn Images.

🎯 No. 1 Houston vs. No. 4 Purdue, 10:09 p.m. ET (TBS/truTV), Midwest Region

Expert pick (Brenden Schaeffer): Houston -7.5 (-115 via BetMGM) vs. Purdue ⭐⭐⭐⭐

🧠 Sweet 16 expert picks

🆚 Sweet 16 game predictions

💰 March Madness betting odds pages

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👑 Best March Madness betting sites

Ready to place your March Madness bets? Check out the best March Madness betting promos from the best March Madness betting sites as determined by our expert team at Sportsbook Review.

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Written By:
Andrew Reid
Andrew is a Publishing Editor at Sportsbook Review. He graduated from Acadia University with a degree in Kinesiology, working as a personal trainer and in injury rehab, and then attended the College of Sports Media in Toronto to attain a diploma in Radio and Television Sports Broadcasting. Andrew has been involved in the sports betting and fantasy sports space since joining the FNTSY Sports Network in 2014, where he worked as a producer, director, and occasional on-air talent on various shows focusing on sports betting and DFS content. Prior to joining SBR, he spent multiple years with the USA Today Network as an editor and writer. Living in Newfoundland, Andrew frequents grey market sportsbooks, but in the past, when he's lived in regulated areas, he's become well-versed with all of our best sportsbooks. As strictly a casual bettor, he enjoys making touchdown parlays with friends (bro-lays), sweating out golf cut parlays during majors, playing same-game parlays for fun, and chasing long-shot bets. He also enjoys using sportsbooks that have solid iGaming and casino platforms. As the old guy on staff, he has an affinity for industry news, which confuses some, but shh ... quiet ... the news is on.