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Sweet 16 Moneyline Odds & Parlay Picks: NCAA Tournament Best Bets

Gabe Henderson

Last Updated: March 27, 2025 7:00 AM EDT • 2 min 5 sec read.

Sweet 16 Moneyline Odds & Parlay Picks: NCAA Tournament Best Bets
Pictured: Houston Cougars guard Emanuel Sharp (21) reacts after a play against the Gonzaga Bulldogs. Photo by Nick Tre. Smith via Imagn Images.

The 2025 NCAA Tournament has favored chalk thus far. While it has led to some scrutiny among spectators, financially backing the betting favorites has been a profitable strategy through the first two rounds.

Our Sweet 16 moneyline odds and parlay picks focus on identifying multiple March Madness winners to open the second weekend of NCAA Tournament play. Favorites of six-plus points are 26-2 straight-up heading into the Sweet 16, so who should you pick for Thursday and Friday?

📊 Sweet 16 moneyline odds

Sweet 16 moneyline odds via BetMGM as of Thursday, March 27.

  • No. 6 BYU Cougars (+180) vs. No. 2 Alabama Crimson Tide (-220)
  • No. 4 Maryland Terrapins (+220) vs. No. 1 Florida Gators (-275)
  • No. 4 Arizona Wildcats (+375) vs. No. 1 Duke Blue Devils (-500)
  • No. 10 Arkansas Razorbacks (+200) vs. No. 3 Texas Tech Red Raiders (-250)
  • No. 6 Ole Miss Rebels (+145) vs. No. 2 Michigan State Spartans (-180)
  • No. 3 Kentucky Wildcats (+165) vs. No. 2 Tennessee Volunteers (-200)
  • No. 5 Michigan Wolverines (+350) vs. No. 1 Auburn Tigers (-450)
  • No. 4 Purdue Boilermakers (+300) vs. No. 1 Houston Cougars (-400)

👉 Check out the full Sweet 16 schedule ahead of the NCAA Tournament matchups on Thursday and Friday.

💎 Best Sweet 16 parlay

We're combining our four best March Madness picks into a lucrative parlay with +603 odds via ESPN BET, which would turn a $10 bet into a $60.30 profit if all four teams win in the NCAA Tournament Sweet 16.

🔥 Parlay: Houston ML + Ole Miss ML + Florida ML + Texas Tech ML (+603 via ESPN BET)

💰 Wager $10 → Win $60.30
💰 Wager $50 → Win $301.50

👉 Want to build a bigger parlay or add more bets for your parlay? Use our parlay calculator to find the best odds for March Madness.

Up To $600 In Bonuses

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🆚 Sweet 16 game predictions

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👑 Best March Madness betting sites

Ready to place your March Madness bets? Check out the best March Madness betting promos from our best March Madness betting sites, as determined by our expert team at Sportsbook Review.

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Written By:
Gabe Henderson
Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC.