Los Angeles Chargers 2025 Schedule, Odds & Predictions: AI Picks for Every Game

We're breaking down everything you need to know about the Chargers, including odds and projections for all 17 games.

Last updated: May 15, 2025 3:20 PM EDT • 4 min read

Los Angeles Chargers 2025 Schedule: Game-by-Game Odds, Predictions & AI Picks — Pictured: Los Angeles Chargers quarterback Justin Herbert runs for a first down. Photo by Jayne Kamin-Oncea / Imagn Images

We're breaking down the Los Angeles Chargers schedule, odds, and predictions for the 2025 NFL season following the official schedule release. The Chargers are projected to win 9.5 games across our best sports betting sites, and we're offering our 2025 win-loss predictions with AI picks for all 17 games.

📅 Los Angeles Chargers 2025 schedule & odds for every game

Odds via DraftKings as of Thursday, May 15. All times listed in Eastern Time.

Week	Date	Opponent	Favorite
1	Friday, Sept. 5 @ 8 PM	vs. Chiefs	Chiefs -3
2	Monday, Sept. 15 @ 10 PM	at Raiders	Chargers -3
3	Sunday, Sept. 21 @ 4:05 PM	vs. Broncos	Chargers -1.5
4	Sunday, Sept. 28 @ 1 PM	at Giants	Chargers -3.5
5	Sunday, Oct. 5 @ 4:25 PM	vs. Commanders	Chargers -1.5
6	Sunday, Oct. 12 @ 1 PM	at Dolphins	Chargers -1.5
7	Sunday, Oct. 19 @ 4:05 PM	vs. Colts	Chargers -6
8	Thursday, Oct. 23 @ 8:15 PM	vs. Vikings	Chargers -3
9	Sunday, Nov. 2 @ 1 PM	at Titans	Chargers -4.5
10	Sunday, Nov. 9 @ 8:20 PM	vs. Steelers	Chargers -4.5
11	Sunday, Nov. 16 @ 1 PM	at Jaguars	Chargers -1.5
12	BYE WEEK	-	-
13	Sunday, Nov. 30 @ 4:25 PM	vs. Raiders	Chargers -6.5
14	Monday, Dec. 8 @ 8:15 PM	vs. Eagles	Eagles -2.5
15	Sunday, Dec. 14 @ 1 PM	at Chiefs	Chiefs -4.5
16	Sunday, Dec. 21 @ 1 PM	at Cowboys	Chargers -1.5
17	TBD	vs. Texans	Chargers -3.5
18	TBD	at Broncos	Broncos -2.5

👉 Check out the full 2025 NFL schedule with odds for every game.

📊 Los Angeles Chargers odds to win Super Bowl & best futures bets

🔎 Our NFL player prop odds tool can help you find the best NFL odds across legal sportsbooks in your area!

💰 Los Angeles Chargers O/U win total

Latest NFL win totals via BetMGM as of Thursday, May 16.

Over 9.5 wins: -110 (bet $10 to win $9.09)
Under 9.5 wins: -110 (bet $10 to win $9.09)

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🔮 Los Angeles Chargers 2025 predictions: Game-by-game picks & final record

Check out our 2025 NFL season predictions for projected standings, playoff results, and award winners - and a breakdown of how our AI model predicts every game.

🤖 Los Angeles Chargers 2025 AI projections

Week 1: Chiefs 30, Chargers 27 ❌
Week 2: Chargers 30, Raiders 21 ✅
Week 3: Chargers 30, Broncos 24 ✅
Week 4: Chargers 26, Giants 20 ✅
Week 5: Chargers 26, Commanders 20 ✅
Week 6: Dolphins 34, Chargers 26 ❌
Week 7: Chargers 28, Colts 24 ✅
Week 8: Chargers 34, Vikings 28 ✅
Week 9: Chargers 29, Titans 17 ✅
Week 10: Chargers 27, Steelers 20 ✅
Week 11: Jaguars 31, Chargers 27 ❌
Week 13: Chargers 28, Raiders 21 ✅
Week 14: Chargers 31, Eagles 30 ✅
Week 15: Chiefs 30, Chargers 24 ❌
Week 16: Cowboys 33, Chargers 31 ❌
Week 17: Chargers 26, Texans 23 ✅
Week 18: Chargers 28, Broncos 24 ✅

🏈 Los Angeles Chargers 2025 record prediction

Projected win-loss record: 12-5

⚡ Los Angeles Chargers Week 1 odds vs. Chiefs

The Chargers battle the Kansas City Chiefs at Corinthians Stadium in Brazil on Friday, Sept. 5. Kickoff is set for 8 p.m. ET. Los Angeles opened as a 3-point underdog.

🔮 2025 NFL season previews & predictions

Following the NFL schedule release, we broke down the odds for every game and asked AI to predict every game (and more). Below are our team-by-team schedules, odds, and predictions for Week 1 through Week 18.

Buffalo Bills	Miami Dolphins	New York Jets	New England Patriots
Baltimore Ravens	Pittsburgh Steelers	Cincinnati Bengals	Cleveland Browns
Houston Texans	Indianapolis Colts	Jacksonville Jaguars	Tennessee Titans
Kansas City Chiefs	Los Angeles Chargers	Denver Broncos	Las Vegas Raiders
Philadelphia Eagles	Washington Commanders	Dallas Cowboys	New York Giants
Detroit Lions	Minnesota Vikings	Green Bay Packers	Chicago Bears
Tampa Bay Buccaneers	Atlanta Falcons	Carolina Panthers	New Orleans Saints
Los Angeles Rams	Seattle Seahawks	Arizona Cardinals	San Francisco 49ers

💵 Best NFL betting sites

Ready to bet on the NFL this season? Check out our best NFL betting sites and the best sportsbook promos for the 2025-26 NFL season:

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Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Written By:
C Jackson Cowart

C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.