Opening NFL Week 1 Odds & Betting Lines: Spread, Over/Under, Moneyline for All 16 Games
The NFL Week 1 schedule and odds are available to bettors, who'll have the next many months to wager on the spread, Over/Under, and/ore moneyline for all 16 games beginning Thursday, Sept. 4 and running through Monday, Sept. 8.
We're highlighting the NFL schedule and opening odds below ahead of the season's opening game between the Dallas Cowboys and Philadelphia Eagles. The Eagles remain favorites by the Super Bowl odds for the upcoming season.
2025 NFL Odds Week 1
NFL odds via DraftKings.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Cowboys vs. Eagles | Eagles -7 | Eagles -310 | 46.5 |
| Chiefs vs. Chargers | Chiefs -3 | Chiefs -155 | 44.5 |
| Cardinals vs. Saints | Cardinals -3.5 | Cardinals -192 | 43.5 |
| Bengals vs. Browns | Bengals -4.5 | Bengals -218 | 44.5 |
| Dolphins vs. Colts | Colts -1.5 | Colts -120 | 45.5 |
| Raiders vs. Patriots | Patriots -3.5 | Patriots -166 | 43.5 |
| Giants vs. Commanders | Commanders -7.5 | Commanders -340 | 45.5 |
| Buccaneers vs. Falcons | Buccaneers -2.5 | Buccaneers -142 | 47.5 |
| Panthers vs. Jaguars | Jaguars -3.5 | Jaguars -166 | 45.5 |
| Steelers vs. Jets | Steelers -2.5 | Steelers -142 | 39.5 |
| Texans vs. Rams | Rams -3.5 | Rams -175 | 44.5 |
| 49ers vs. Seahawks | 49ers -1.5 | 49ers -120 | 45.5 |
| Titans vs. Broncos | Broncos -7.5 | Broncos -375 | 43.5 |
| Lions vs. Packers | Packers -1.5 | Packers -118 | 47.5 |
| Ravens vs. Bills | Bills -1.5 | Bills -122 | 51.5 |
| Vikings vs. Bears | Bears -1.5 | Bears -122 | 45.5 |
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The NFL Week 1 odds are live. Betting lines will move over the next three-plus months based on training camp developments, player injuries, and roster movement.
The early odds from our best sports betting sites list the home team as the favorite in 10 of 16 matchups.
Season opener: Cowboys vs. Eagles, Thursday, Sept. 4 (8:20 p.m. ET, NBC)
As is tradition, the Super Bowl champions play in the NFL's Thursday opener. This time, the Eagles host the rival Cowboys at Lincoln Financial Field in Philadelphia. The reigning Super Bowl champs are 7-point betting favorites by the opening Cowboys vs. Eagles odds. Our Gabe Henderson looks at the opening Cowboys vs. Eagles anytime touchdown scorer odds.
When is Cowboys vs. Eagles Week 1?
- When: Thursday, Sept. 4
- Kickoff: 8:20 p.m. ET
- Where: Lincoln Financial Field (Philadelphia)
- How to watch: NBC
- Betting favorite: Eagles (-7 via DraftKings) | Over/Under: 46.5 (-110/-110)
Chiefs vs. Chargers, Friday, Sept. 5 (8:15 p.m. ET, YouTube)
Cardinals vs. Saints, Sunday, Sept. 7 (1 p.m. ET)
Bengals vs. Browns, Sunday, Sept. 7 (1 p.m. ET)
Dolphins vs. Colts, Sunday, Sept. 7 (1 p.m. ET)
Raiders vs. Patriots, Sunday, Sept. 7 (1 p.m. ET)
Giants vs. Commanders, Sunday, Sept. 7 (1 p.m. ET)
Buccaneers vs. Falcons, Sunday, Sept. 7 (1 p.m. ET)
Panthers vs. Jaguars, Sunday, Sept. 7 (1 p.m. ET)
Steelers vs. Jets, Sunday, Sept. 7 (1 p.m. ET)
Texans vs. Rams, Sunday, Sept. 7 (4 p.m. ET)
49ers vs. Seahawks, Sunday, Sept. 7 (4 p.m. ET)
Titans vs. Broncos, Sunday, Sept. 7 (4 p.m. ET)
Lions vs. Packers, Sunday, Sept. 7 (4 p.m. ET)
Ravens vs. Bills, Sunday, Sept. 7 (8:20 p.m. ET, NBC)
Vikings vs. Bears, Sunday, Sept. 7 (8:15 p.m. ET, ESPN)
NFL Week 1 odds and lines
There's an advantage to betting the early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your NFL picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
That's why it's important to start monitoring the NFL opening odds each week as soon as possible. A proactive approach is the first step to long-term success.
🗓️ Early 2025-26 NFL odds
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🏟️ NFL betting odds pages
💵 Best NFL betting sites
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