Way Too Early NFL Week 18 Odds & Betting Lines: Spreads and Totals for All 16 Games
The NFL's Week 18 - the final week of the regular season - is schedule for Sunday, Jan. 4. That's not stopping us from having (way too) early NFL Week 18 odds and betting lines.
The NFL schedule and opening odds for all 272 regular-season games give bettors an idea of how our best sports betting sites think the 2025-26 season will play out. The reigning Super Bowl champion Philadelphia Eagles are 7-point betting favorites against the Dallas Cowboys, according to the opening NFL Week 1 odds and betting lines, but where do they stand in Week 18?
Study these odds before making your 2025 NFL season predictions.
📊 2025 NFL Odds Week 18
NFL odds via DraftKings.
| Date | Matchup | Favorite |
|---|---|---|
| TBD | Jets at Bills (-9.5) | Bills -380 |
| TBD | Dolphins at Patriots (-2.5) | Patriots -130 |
| TBD | Ravens (-4.5) at Steelers | Ravens -198 |
| TBD | Browns at Bengals (-8.5) | Bengals -380 |
| TBD | Colts at Texans (-4.5) | Texans -198 |
| TBD | Titans at Jaguars (-4.5) | Jaguars -192 |
| TBD | Chargers at Broncos (-2.5) | Broncos -130 |
| TBD | Chiefs (-6) at Raiders | Chiefs -250 |
| TBD | Cowboys (-1.5) at Giants | Cowboys -120 |
| TBD | Commanders at Eagles (-4.5) | Eagles -198 |
| TBD | Lions (-1.5) at Bears | Lions -122 |
| TBD | Packers (-1.5) at Vikings | Packers -120 |
| TBD | Saints at Falcons (-4.5) | Falcons -218 |
| TBD | Panthers at Buccaneers (-7) | Buccaneers -298 |
| TBD | Cardinals at Rams (-3.5) | Rams -175 |
| TBD | Seahawks at 49ers (-4.5) | 49ers -198 |
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The NFL odds for Week 18 are live, and you can already make your best predictions for games that won't be played for nearly eight months. There's a full 16-game schedule - with all games on Sunday, Jan. 4 - and each game has a spread and moneyline set at DraftKings.
The Buffalo Bills (-9.5) and Cincinnati Bengals (-8.5) are the two biggest favorites of Week 18, laying more than a touchdown against the New York Jets and Cleveland Browns, respectively.
Injuries - not just in training camp and the preseason but over the regular season's first 17 weeks - will shift these lines. Player movement, coaching changes, and team and player performance will also impact the odds. Playoff positioning will also be on the line in the season's final week.
It's time to dust off your crystal ball and forecast the entire NFL season.
NFL Week 18 odds and lines
There's an advantage to betting the early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your NFL picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
That's why it's important to start monitoring the NFL opening odds each week as soon as possible. A proactive approach is the first step to long-term success.
🔮 2025 NFL season previews & predictions
Following the NFL schedule release, we broke down the odds for every game and asked AI to predict every game (and more). Below are our team-by-team schedules, odds, and predictions for Week 1 through Week 18.
- NFL Week 1 odds and schedule
- NFL Week 1 picks against the spread
- NFL International schedule and odds
- NFL Thanksgiving schedule and odds
- NFL Christmas schedule and odds
- NFL Week 18 odds and schedule
- Best revenge games for the 2025-26 season
🏟️ NFL betting odds pages
💵 Best NFL betting sites
Ready to bet on the NFL this season? Check out our best NFL betting sites and the best sportsbook promos for the 2025-26 NFL season:
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